Oncology_Logotype-site-1Oncology_Logotype-site-1Oncology_Logotype-site-1Oncology_Logotype-site-1
  • Main
  • Сlinical Trials
    • Completed phase I/IIa clinical trial
    • Case studies
    • Ex-US Clinical Trials
    • US clinical trials
  • Dogs & Cats
    • Comparative Medicine and Veterinary Research
  • Elenagen
    • Elenagen is a Plasmid (Circular DNA) Encoding Gene P62/SQSTM1
    • Elenagen Reduces/Reverts Tumor Grade
    • Elenagen Changes Tumor Microenvironment
    • Elenagen Downregulates Chronic Inflammation
    • Elenagen Enhances Anti-Tumoral Immune Response
  • IP
  • Publications
  • Investors
    • One-pager
    • Slide presentation
  • Team
    • Management Team
    • Scientific Advisory Board
    • Board of Directors
    • Careers
  • News
    • Company news
    • In the news
  • Legal
CureLab Oncology Submits Patent for COVID Therapeutic Ahead of Phase I Clinical Trials
June 30, 2021
Hormone-Resistant Prostate and Breast Cancers Added to Clinical Study Based on Encouraging Preliminary Results
August 11, 2021
July 20, 2021

CureLab Oncology Granted US Patent for Therapeutic Use of its Lead Product in ALS, Alzheimer’s, Huntington’s, and Parkinson’s Diseases

Patent makes it feasible to commence clinical trials to establish effectiveness of its lead product and product variations for treatment of neurodegenerative diseases
image

BOSTON – July 20, 2021: CureLab Oncology, a clinical-stage biotech company, has been granted a US patent for the application of its lead product for the treatment of ALS, Alzheimer’s, Huntington’s, and Parkinson’s disease. These patent applications were already granted in Asia and Europe.

Today, 5 million Americans suffer from Alzheimer’s, 1 million from Parkinson’s, 30,000 from Huntington's disease, and 30,000 from ALS. The incidence of these diseases is expected to soar as the population ages.

“Our current product is a circular DNA encoding a particular protein, p62. However, it can be modified to a vast variety of alternate forms, including a therapeutic microbiome. In fact, we recently published a paper demonstrating that Lactobacillus lactis containing a circular DNA with an inserted p62 gene reduced signs of Alzheimer’s in mice. All of these alternate products are covered by the granted patent,” said Dr. Franco Venanzi, CureLab’s director of basic research.

CureLab’s research is focused on a new strategy for treatment of these diseases since neurodegenerative diseases, like some cancers, involve chronic inflammation in their pathogenesis. CureLab’s lead product, Elenagen™, reduces chronic inflammation. In its ongoing cancer clinical studies, CureLab has observed a desirable safety profile and a preliminary evidence of clinical benefits of Elenagen for cancer patients.

“With this patent, we continue to expand, strengthen and protect our worldwide p62-based gene therapy patent estate,” said Alexander Shneider, Ph.D., CEO of CureLab Oncology. “Alternate applications of our product became evident through mechanistic insights into its anti-cancer effect. This anti-neurodegenerative dimension to our work does not distract us from our cancer clinical trials—rather, it adds a synergistic component to our R&D.”

CureLab plans clinical trials to establish effectiveness of its lead product and product variations for treatment of neurodegenerative diseases.

For more information, see “Neuroprotective effects of p62(SQSTM1)-engineered lactic acid bacteria in Alzheimer’s disease: a pre-clinical study” in Aging, August 29. 2020.

About CureLab Oncology

CureLab Oncology Inc. is a clinical-stage immuno-oncology biotech company headquartered in the greater Boston area. CureLab is dedicated to advancing new and safer therapeutics for solid tumors and other oncology and inflammatory indications. To learn more, visit curelaboncology.com.

Media contact:

Tim Cox, ZingPR, tim@zingpr.com

Share

Related posts

November 5, 2022

Biotech Internship Opportunity! FDA/USDA liaison


Read more

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Corporate Mission

CureLab Oncology is a biotechnology company that is developing new anti-cancer biologics.
CureLab Oncology is committed to creating a family of revolutionary
therapies for oncology patients in order to help prolong their lives.

Our Lead Product

Our lead product, Elenagen, is a plasmid (supercoiled circular DNA) encoding gene p62/SQSTM1. Elenagen reverses tumor grade, changes tumor microenvironment, enhances the anti-cancer effects of other therapies (e.g. chemotherapy), mitigates chronic inflammation, and stimulates an immune attack on the tumor.

Clinical Trials

  • The CureLab Oncology team has completed its international Phase I/IIa Clinical Trials of Elenagen.
  • The vaccine demonstrated a high degree of safety as well as clinical benefits in a number of patients.
  • We are now preparing Phase II Clinical Trials within the US.

Contact us

E-mail:

info@curelab.com,

Call us:

1-609-841-1201

177 HUNTINGTON
AVE FL 17
BOSTON MA 02115-3156
© 2020 CureLab Oncology.