A novel DNA-based therapy achieves significant increase in overall survival in platinum resistant ovarian cancer
January 13, 2026
Therapy could increase ovarian cancer survival, paper finds – Drug Discovery World (DDW)
January 15, 2026Novel DNA-Based Therapy Called Elenagen, from CureLab Oncology, Achieves Significant Reduction in Mortality and an Increase in Overall Survival in Platinum‑Resistant Ovarian Cancer - BioQuick News
Peer-reviewed in the International Journal of Gynecological Cancer
Elenagen plus chemotherapy lived significantly longer than those who received chemotherapy alone
Median overall survival increased from approximately 13 months to over 25 months
A new clinical study published January 7, 2026 in the International Journal of Gynecological Cancer reports encouraging results for women facing platinum-resistant ovarian cancer PROC). Researchers evaluated a novel DNA-based therapy called Elenagen, administered in combination with the standard chemotherapy, gemcitabine, in women with PROC and elevated CA-125. Elenagen is a plasmid therapy—a small, circular piece of DNA encoding the protein p62/SQSTM1 — currently being developed by CureLab Oncology, Inc. In the randomized Phase II trial, Elenagen was administered once weekly via a simple intramuscular injection. In the reporting, researchers supplementing the standard of care (chemotherapy) with Elenagen, have significantly extended overall survival for patients with the deadliest form of ovarian cancer. The open-access article is titled “Elenagen, a p62/SQSTM1-Encoding Plasmid, Improves Overall Survival in Platinum-Resistant Ovarian Cancer Patients: A Phase II Trial.”
Ovarian cancer remains one of the most lethal cancers affecting women. Approximately 1 in 80 women will develop the disease during her lifetime. Each year, over 12,000 women die of the disease in the U.S., and over 200,000 worldwide. While many women initially respond to chemotherapy, the cancer recurs in the majority of cases. Effectively, all women with recurrent cancer eventually develop platinum-resistant ovarian cancer. At this point, treatment options are extremely limited, response rates are low, and average survival is often measured in months, frequently accompanied by significant side effects. Among these patients, those with elevated CA-125 levels have the poorest prognosis.
Key Study Findings
The paper describes key study findings in this randomized Phase II clinical trial:
- Extended Survival: Women who received Elenagen plus chemotherapy lived significantly longer than those who received chemotherapy alone.
- Doubled Median Overall Survival: Median overall survival increased from approximately 13 months to over 25 months.
- Reduced Mortality: The risk of death was reduced by nearly 60%.
- High Safety Profile: Importantly, the addition of Elenagen did not increase treatment-related toxicity.
- Long-Term Responders: Some patients receiving Elenagen survived several years beyond typical expectations for this clinical setting.
“As a gynecologic oncologist, I see firsthand how devastating platinum-resistant ovarian cancer is for patients and their families,” said Dr. Gabriel Levin, gynecologic oncologist at McGill University Health Centre and co-author of the study. “What makes these findings so meaningful is not only the improvement in survival but the fact that this was achieved without adding toxicity. Our hope is that therapies like Elenagen can shift how we think about cancer treatment by supporting the body’s biology rather than simply escalating chemotherapy.”
Unexpected Scientific Insight from Historical Circumstances
Due to the military situation in the region, all patients in this ex-U.S. trial synchronously stopped receiving Elenagen when new supplies could not be delivered. By that time, treatment durations ranged from 0.7 months to over 30 months. While the original study design intended for administration to continue indefinitely, these circumstances provided serendipitous insights for future trials.
Longer administration of Elenagen strongly correlated with longer patient survival after treatment was terminated. This effect was most evident during the first 12 months, with diminishing—though still significant—extension in life expectancy at 18 months. Consequently, the extended overall survival reported in the paper is considered a “lower bound” because it includes patients who received the therapy forinsufficient duration. In planned U.S. and EU trials, CureLab will offer Elenagen for 24 months, as data suggests further treatment may offer no additional benefit.
How Elenagen Works Against Cancer
Elenagen’s ability to reduce chronic inflammation alters the intratumoral microenvironment, facilitating the penetration of immune cells (Tumor-Infiltrating Lymphocytes, or TILs). Simultaneously, it impairs metastatic cells’ ability to exit the tumor and form remote lesions, while preventing the tumor from suppressing the active immune response.
“My original idea was simple when I first proposed using DNA encoding the p62 protein as a cancer therapeutic vaccine: cancer cells produce too much p62 and are ‘addicted’ to it, so we aimed to train the immune system to recognize and eliminate them eliciting anti-p62 immune response. The rest came as serendipitous discoveries,” says Alexander Shneider, PhD, CEO of CureLab Oncology, inventor of Elenagen, and senior author of the paper. “However, nature is always more complex than we model it to be. Humbly following those unexpected signals gave us new insight into where existing standards of care fail — and how Elenagen may help fill those gaps.”
Future Studies
“FDA and regulators worldwide grant market authorization for anti-PROC treatments based on progression-free survival (PFS)—the timespan during which the primary tumor and metastases remain relatively stable,” says Dr. Shneider. “We demonstrated that Elenagen increased PFS in our previous paper https://pubmed.ncbi.nlm.nih.gov/38410116/. To our team, that was not enough; today, we are proud to report a highly statistically significant increase in overall survival. Yet even that is not my ultimate goal.”
Dr. Shneider and his team aim to secure a high quality of life for cancer patients. Many comorbidities in cancer stem from chronic inflammation. For example, chronic inflammation contributes to chronic pain or systemic toxicity that many cancer patients experience. Also, chemo agents induce chronic inflammation, which in turn deactivates these agents. Because Elenagen systemically reduces chronic inflammation, researchers anticipate it to become a treatment with “positive side effects.” Comprehensive monitoring of quality of life was not a part of the conducted studies (only anecdotal self-reports from the patients), but it will be an endpoint in the future US/EU trial.
CureLab is currently planning Phase II/III clinical trials in the U.S. and EU. The protocol was designed in collaboration with the Gynecologic Oncology Group (GOG) Foundation, a leading group of key opinion leaders in the field. In addition to PROC, the company plans to conduct FDA clinical trials for the deadliest form of breast cancer.
About Elenagen
CureLab’s lead investigational compound is code-named Elenagen, an experimental DNA therapy that consists of a circular piece of DNA, a plasmid, that encodes a human protein called p62/SQSTM1. In clinical studies conducted outside the US, Elenagen demonstrated a desirable safety profile and statistically significant clinical benefit for cancer patients by enhancing the anti-cancer effects of chemotherapy. Experimental results also indicate mitigation of chronic inflammation, anti-aging effects, and stimulation of an immune response to the tumor.
About CureLab Oncology
CureLab Oncology Inc. is a clinical-stage biotech company headquartered in the greater Boston area, Massachusetts. CureLab is dedicated to advancing new and safer therapeutics for solid tumors and other oncology and inflammatory indications. To learn more, visit curelaboncology.com.
